Our Pipeline

Using our Protein Painting technology, we are identifying high-impact therapeutic targets across a broad spectrum of diseases.  We are currently focused on 3 therapeutic areas:  inflammation, cancer and wound healing.   Inflammation is our most advanced program.

Inflammation

Inflammation is an area of significant unmet need and an attractive market opportunity as inflammation is a significant component of a wide variety of disease states  For example, the osteoarthritis market is expected to reach $3.5 billion globally by 2026 with a compound annual growth rate of 8.1%, while the  gout market is expected to reach $8.3 billion globally by 2025 with a compound annual growth rate of 16.1%.

Monet is focused on targeting inflammatory cytokine signaling.  Many companies have focused on certain cytokines like IL-1B.  Monet is focused on one of Il-1B’s partners – IL-1RAcP, which is present at lower concentrations and is essential for inflammatory signaling.   Monet has discovered the specific place that IL-1RAcP uses to engage with IL-1B and start inflammatory signaling. Monet compounds developed against this site have proven effective in-vitro as well as in animal models

Cancer

Immunotherapies for cancer treatment are poised to become the best-selling drugs of the future - Biggest Blockbuster Drugs. Keytruda, a new anti-PD-1 immunotherapy therapy, is predicted to represent a full 5% of global oncology sales by 2026 all by itself: Read Forbes Magazine.  Much of this growth in immunotherapy is based on the powerful modality of blocking interaction between two specific proteins: PD-1 and PD-L1.

Monet is focused on targeting this protein-protein interaction in a new way. Most companies have focused on antibody therapies because small molecule therapies have been very unsuccessful. Using protein painting, Monet has discovered a unique location of the interface that allows for potent and specific targeting of the protein-protein interaction, while enabling the development of treatments at the small-molecule and peptide level. Monet compounds developed against this site have proven effective in vitro and represent opportunities to enter this significant market with safer, smaller compounds.

Wound Healing

Wound healing is a unique market with invested parties including governments and militaries around the world desirous of more efficacious treatments for wounded soldiers, in addition to private domestic interest in the treatment of chronic wounds: Advanced Wound Care Market by Product Type.  The global wound-healing market is predicted to be over $35 billion by 2025 and represents unique opportunities for public/private partnerships: Global Wound Healing Market.

Monet is focused on targeting proteins involved in Hippo pathway signaling. This pathway governs growth and differentiation of cells, and cross-talks with cellular mechano-sensing pathways. This means that Hippo pathway proteins are a unique bridge between sensing a wound’s presence and turning on growth molecules to heal it. Monet has discovered unique interfaces between YAP2, a member of the Hippo pathway, and ZO-1, a part of the cell’s mechano-sensing architecture. Monet compounds developed against these sites are currently under development.