Monet Pharmaceuticals' proprietary Protein Painting technology, co-discovered by a team of scientists from George Mason University, is an and elegant structural biology technique designed to identify new protein-protein (P2P) interactions using custom designed dye chemistries and mass spectrometry.   

Protein-protein interactions are the future of drug discovery.  Current methods used to identify interactions between multiple proteins  are not only time and labor intensive, but can be ineffective for challenging proteins. Many proteins are simply too dynamic in their native water-based environment or too insoluble in special imaging solutions to allow for the use of traditional visualization technologies that many companies favor. Some proteins also require manipulation or modification to allow than to be visualized. This risks capturing forced interactions rather than natural ones.

Protein Painting addresses some of the challenges of other techniques.   Protein Painting is faster than all other methods, significantly reducing the time needed to identify the valuable interaction points between proteins with therapeutic potential. It also has the highest rate of true positives, as the technology output is calibrated to return only high-confidence interface regions. It  requires no modification to the actual structure of the proteins involved and no special software for data analysis. It is specially designed for compatibility in the native water-based environment of proteins, allowing for results that reflect how proteins interact naturally.

Protein Painting accelerates and simplifies the drug discovery process, paving the way for progress and innovation. The protein painting platform is versatile and can be applied to facilitate the discovery of novel therapeutics across a diverse range of disease states.  Fundamentally, Protein Painting provides a unique insight into the interactions between proteins that differs from that provided by other methods. 

In short, Protein Painting is faster, simpler and more effective.

PUBLICATIONS

Protein painting technology has been widely published in well-respected, peer-reviewed journals such as Nature Communications, Immunity and the Journal of Biochemistry.